from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The removal of a proton (hydrogen ion) from a molecule to form a conjugate base
Sorry, no etymologies found.
The droplet leaches its acid into the surrounding solution, losing hydrogen ions in a process known as deprotonation - a process that affects the surface tension of the droplet itself.
Those tiny pH differences affect the amount of deprotonation that happens at the front and rear of the droplet, and this asymmetry sets up a surface tension gradient that forces the droplet into motion.
Two recent articles published by Baker's team in collaboration with several other leading protein research groups reveal exciting early progress on this front, including the successful design of a novel enzyme that catalyzes the Kemp elimination, a chemical reaction involving the deprotonation of a carbon atom.
The formation of a secondary alcohol via reduction and hydration is shown: Reactions Deprotonation Alcohols can behave as weak acids, undergoing deprotonation.
When a Brönsted-Lowry acid goes through deprotonation
When a Brönsted-Lowry acid goes through deprotonation (the process of losing a proton) it forms something that will readily receive a proton, forming the conjugate base.
Assuming a pK a of 10, as is usual for a Tyr residue, then deprotonation of Tyr419 will further increase the barrier to