Definitions
from the GNU version of the Collaborative International Dictionary of English.
- noun (Biochem.) the process of testing samples of mixtures which are active in a screening process, so as to recognize and eliminate from consideration those active substances already studied; -- a stage subsequent to the preliminary screening in the process of discovery of new pharmacologically active substances in mixtures of natural products; -- also called
counterscreening . Seescreening .
Etymologies
Sorry, no etymologies found.
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Examples
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Second, the researchers created "dereplication" tools for moving the other direction: taking the chemical structures of known NRPs and other related information and determining what the data signature would look like if a mass spectrometer had blown the compound part.
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Bruker's dedicated MALDI Biotyper solution enables molecular identification, taxonomical classification or dereplication of microorganisms like bacteria, yeasts and fungi.
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With dereplication, researchers can leverage known information and are not forced to start from scratch each time a new compound needs to be identified.
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Though I believe there are other uses too, for example, in between sample alignment, the recovery of a full mass spectrum is particularly important for metabolite identification of new, yet unknown compounds (yes, even dereplication is already non-trivial, because of the lack of free (open data preferably), machine accessible (open standards!) database of mass spectra (using different ionization methods).
Archive 2008-06-01 Egon Willighagen 2008
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Though I believe there are other uses too, for example, in between sample alignment, the recovery of a full mass spectrum is particularly important for metabolite identification of new, yet unknown compounds (yes, even dereplication is already non-trivial, because of the lack of free (open data preferably), machine accessible (open standards!) database of mass spectra (using different ionization methods).
Recovering full mass spectra from GC-MS data Egon Willighagen 2008
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