Definitions
from The Century Dictionary.
- noun A colorless levorotatory glucoside, C27H46O145H2O, found in commercial digitalin. It crystallizes in slender needles which soften and turn yellow at 235° C.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun organic chemistry A
glycoside , obtained from Digitalis purpurea, that is used as adetergent and whoseaglycone is digitogenin.
Etymologies
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Examples
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At a higher EGCG concentration (200 µg/ml) the additional effect of digitonin was more pronounced and detected already after less than 2 h.
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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Following, 25 µl of EGCG (Sigma) or digitonin (Sigma) were mixed with 2 µl SYTOX-Orange (100 µM stock, Invitrogen) and added to the parasite solution.
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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It is likely that besides causing membrane disruption digitonin promotes the transport of EGCG inside the parasite.
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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A clear shift towards an increased toxic effect of EGCG by digitonin application was only reached by a combination of EGCG with 60 µg/ml or 70 µg/ml digitonin.
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In order to verify this methodology, we probe here the effect of EGCG in combination with the adjuvant digitonin as a membrane permeabilising agent on Effect of EGCG on Plasmodium Sporozoite Survival, Motility, and Liver Cell Infection
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Addition of 40 µg/ml or 50 µg/ml digitonin resulted in similar concentration curves as application of EGCG alone during the first 10 h.
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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Only after more than 10 h an effect of these digitonin concentrations was detected.
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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To probe for such effects, we tested the green tea compound epigallocatechin gallate (EGCG) and the membrane permeabilising digitonin on
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Using the membrane permeabilising saponin digitonin, we measured digitonin applications of different concentrations in cytotoxicity assays over 18 h alone to normalise the data of the combination treatment of EGCG and digitonin against the toxic effect the adjuvant already determines alone.
PLoS ONE Alerts: New Articles Janina K. Hellmann et al. 2010
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The values were averaged over triplicates (each containing 200 to 300 parasites) and normalised to the cytotoxicty assay of 40 µg/ml to 70 µg/ml digitonin without EGCG application measured over
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