dominant-negative

We also demonstrated that endocytosis of Fc αR was dynamin-dependent by overexpressing a dominant-negative mutant of dynamin.

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We also demonstrated that endocytosis of Fc αR was dynamin-dependent by overexpressing a dominant-negative mutant of dynamin.

Naturejobs - All Jobs Min Peng 2010

Accordingly, knock-down of GRASP-1 mimics the effects of dominant-negative Rab4 and Rab11 on dendritic spine morphology.

PLoS Biology: New Articles Casper C. Hoogenraad et al. 2010

By using selective chemical inhibitors of different endocytic pathways, overexpression of dominant-negative mutants of Eps15 and knockdown of clathrin heavy chain (CHC) via RNA interference, we demonstrated that endocytosis of Fc αR was through a clathrin-mediated pathway.

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However, endocytosis of Fc αR could not be blocked by a dominant-negative mutant of Rab5.

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Therefore, we proposed that Cx26R184Q has a dominant-negative effect on the function of WT Cx26 and

Naturejobs - All Jobs Ching-Chyuan Su 2010

/Bak DKO cells, and that autophagic cell death was suppressed by the addition of a JNK inhibitor and by a dominant-negative mutant of JNK.

Naturejobs - All Jobs S Shimizu 2010

This result suggests that activation of cap-independent translation by ZNF9 is somehow blocked in DM2 cells, possibly through a dominant-negative action of the expanded repeat RNA.

PLoS ONE Alerts: New Articles Morgan A. Sammons et al. 2010

The extracellular small GTPase RhoA/ROCK-2 cascade mediated the increased moesin expression and phosphorylation, which was discovered by the use of Y-27632, a specific inhibitor of Rho kinase and by transfected constitutively active, dominant-negative RhoA as well as ROCK-2 SiRNA.

BioMed Central - Latest articles Mian He 2010

By using selective chemical inhibitors of different endocytic pathways, overexpression of dominant-negative mutants of Eps15 and knockdown of clathrin heavy chain (CHC) via RNA interference, we demonstrated that endocytosis of Fc αR was through a clathrin-mediated pathway.

Naturejobs - All Jobs Min Peng 2010