Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry A
microtubule -associatedprotein expressed by neuronal precursor cells and immature neurons in embryonic and adult cortical structures.
Etymologies
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Examples
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"We study the gene" doublecortin, "which is defective in some forms of epilepsy and mental retardation in humans," said Kerjan, lead author of the study.
THE MEDICAL NEWS 2009
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For quantification of neurogenesis, the number of doublecortin-positive cells embedded within the granule cell layer of the dentate gyrus were counted in three sections spanning the dorsal hippocampus by an independent observer.
PLoS ONE Alerts: New Articles Pramod K. Dash et al. 2010
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As the animals used for this analysis were euthanized approximately 4 weeks after injury, it is possible that the neurons generated during the time of VPA administration (given during the first week of injury) had become synaptically integrated and were no longer doublecortin positive.
PLoS ONE Alerts: New Articles Pramod K. Dash et al. 2010
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Representative photomicrographs showing doublecortin immunoreactivity from a
PLoS ONE Alerts: New Articles Pramod K. Dash et al. 2010
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It has been reported that doublecortin is expressed during the late mitotic and early post-mitotic stages of neurogenesis (1-3 weeks post proliferation) [54], [55].
PLoS ONE Alerts: New Articles Pramod K. Dash et al. 2010
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Although we anticipated seeing an influence of VPA on the rate of hippocampal neurogenesis, our analysis of doublecortin positive cells examined after the completion of behavioral training did not reveal any significant increase in cell numbers relative to that observed in vehicle-treated, injured animals.
PLoS ONE Alerts: New Articles Pramod K. Dash et al. 2010
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"However, only after we removed a combination of two of the genes in the doublecortin family did we uncover epilepsy."
THE MEDICAL NEWS 2009
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Brown JP, Couillard-Despres S, Cooper-Kuhn CM, Winkler J, Aigner L, et al. (2003) Transient expression of doublecortin during adult neurogenesis.
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BrdU, bromo-deoxy-uridine; cdk5, cyclin-dependent kinase 5; DCX, doublecortin; GCL, granule cell layer; GFP, green fluorescent protein; ML, molecular layer; NPC, neural stem and progenitor cell; RFP, red fluorescent protein; shRNA, small hairpin RNA
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Tanaka T, Serneo FF, Tseng HC, Kulkarni AB, Tsai LH, et al. (2004) Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration.
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