Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun
modulation to a lower level
Etymologies
Sorry, no etymologies found.
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Examples
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We demonstrated a significant downmodulation of the main pathways implicated in bone and cartilage destruction in RA: the MMP / TIMP system and the OPG / RANKL system.
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• Therapy with TNF antagonists such as etanercept and infliximab is highly active in patients with RA through downmodulation of both synovial inflammation and cartilage and bone destruction.
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Altogether, these results show that zinc counteracted hypoxia-induced HIPK2 downmodulation, recovered the HIPK2 recruitment onto chromatin and led to repression of the HIF-1 pathway.
PLoS ONE Alerts: New Articles Lavinia Nardinocchi et al. 2009
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Notably, zinc supplementation to hypoxia-treated cells counteracted the inhibition of HIPK2 allowing its nuclear accumulation that correlated with HIF-1α downmodulation and repression of the HIF-1 pathway and with restoration of p53Ser46 apoptotic transcriptional activity in response to drug.
PLoS ONE Alerts: New Articles Lavinia Nardinocchi et al. 2009
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