downmodulation love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. modulation to a lower level

Etymologies

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Examples

  • We demonstrated a significant downmodulation of the main pathways implicated in bone and cartilage destruction in RA: the MMP / TIMP system and the OPG / RANKL system.

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  • • Therapy with TNF antagonists such as etanercept and infliximab is highly active in patients with RA through downmodulation of both synovial inflammation and cartilage and bone destruction.

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  • Altogether, these results show that zinc counteracted hypoxia-induced HIPK2 downmodulation, recovered the HIPK2 recruitment onto chromatin and led to repression of the HIF-1 pathway.

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  • Notably, zinc supplementation to hypoxia-treated cells counteracted the inhibition of HIPK2 allowing its nuclear accumulation that correlated with HIF-1α downmodulation and repression of the HIF-1 pathway and with restoration of p53Ser46 apoptotic transcriptional activity in response to drug.

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