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- n. modulation to a lower level
Sorry, no etymologies found.
We demonstrated a significant downmodulation of the main pathways implicated in bone and cartilage destruction in RA: the MMP / TIMP system and the OPG / RANKL system.
• Therapy with TNF antagonists such as etanercept and infliximab is highly active in patients with RA through downmodulation of both synovial inflammation and cartilage and bone destruction.
Altogether, these results show that zinc counteracted hypoxia-induced HIPK2 downmodulation, recovered the HIPK2 recruitment onto chromatin and led to repression of the HIF-1 pathway.
Notably, zinc supplementation to hypoxia-treated cells counteracted the inhibition of HIPK2 allowing its nuclear accumulation that correlated with HIF-1α downmodulation and repression of the HIF-1 pathway and with restoration of p53Ser46 apoptotic transcriptional activity in response to drug.