from Wiktionary, Creative Commons Attribution/Share-Alike License

  • v. Third-person singular simple present indicative form of downregulate.


Sorry, no etymologies found.


  • In contrast, we show here that N-cadherin overexpression downregulates PI3K and Akt activity which mediates in part the negative effect of N-cadherin on osteoblast growth and survival.

    PLoS ONE Alerts: New Articles

  • Prof. ZAK: When someone does something nice for you - holds a door - your brain releases this chemical and it downregulates the appropriate fear we have of interacting with strangers.

    When The 'Trust Hormone' Is Out Of Balance

  • Once colonized, the squid dismantles the harvesting cilia and downregulates the secretion of mucus.

    No metazoan is an island - The Panda's Thumb

  • So to save your life the metabolism downregulates.

    Gary Taubes responds | The Blog of Michael R. Eades, M.D.

  • There is a reality that is obvious in asthma, shown by albuterol-type “rescue” inhalers, very dangerous because their constant use downregulates the number of epi-receptors, creating the need for MORE, not to mention fostering dependence.

    Inflammation and diet | The Blog of Michael R. Eades, M.D.

  • In experimental feeding in monkeys you can see that it actually downregulates a specific immune system modulator.

    Laurie Garrett on lessons from the 1918 flu

  • Chiarini, F.e.a., The novel Akt inhibitor, perifosine, induces caspase-dependent apoptosis and downregulates P-glycoprotein expression in multidrug-resistant human T-acute leukemia cells by a JNK-dependent mechanism.

  • Here, we discovered that dexamethasone downregulates Lck, which, in turn, suppresses lymphocyte activation by inhibiting pro-survival calcium oscillations.

    Naturejobs - All Jobs

  • Onouchi and colleagues have previously identified another KD-associated variation (or SNP) in the gene encoding inositol 1,4,5-trisphosphate 3 kinase-C (ITPKC), an enzyme that downregulates a T cell signaling cascade in which calcium ion (Ca2+) flux is coupled with NFAT activation2.


  • B. PMA induces hres expression while PDTC downregulates it.

    PLoS ONE Alerts: New Articles


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