Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. The process, in the regulation of gene expression, in which the number, or activity of receptors decreases in order to decrease sensitivity
Etymologies
Sorry, no etymologies found.
Examples
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The logical first step, then, is to protect the cell before damage occurs, including the cell membrane, mitochondria, and DNA, as well as the downregulation of inflammatory genes.
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As insulin loses function, more insulin is required, more insulin leads to more downregulation of receptors, all of which ultimately leads to obesity.
Changing dietary trends and the obesity epidemic | The Blog of Michael R. Eades, M.D.
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In gaining muscle mass, one of his recommendations is to “drop calories by 50% one day per week to prevent protein uptake downregulation.”
Intermittent fasting guest blog | The Blog of Michael R. Eades, M.D.
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One study has also shown that dexamethasone (DEX) contributed to the downregulation of MAM-induced IL1B and TNF -.
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Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, et al. (2006) Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death.
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A key proposition that underpins our understanding of dosage sensitivity is that duplication or deletion of the genomic region containing a gene will result in a significant up - or downregulation of expression of the gene
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Does the downregulation of the FGF23 signaling pathway in hyperplastic parathyroid glands contribute to refractory secondary hyperparathyroidism in CKD patients
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Examination of various SNc neuronal markers indicated that neurodegeneration was due to cell loss and not just downregulation of DA synthesis.
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Moreover, co-expression of both rat α-syn and α-syn siRNA partially reversed the neurodegenerative and behavioral effects of α-syn plays an important role in the rat SNc and suggest that both up - and downregulation of wild-type
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We conclude that RA treatment leads to premature downregulation of Oct4 and partial derepression of Xist irrespective of X-chromosome counting.
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