Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A protein that is linked with skeletal muscle repair

Etymologies

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Examples

  • In this study we have analyzed the dysferlin protein domains and

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  • French Canadian cases were found to develop proximal limb girdle muscular dystrophy, usually in the thirties, while European cases developed a more distal non-dysferlin Miyoshi Myopathy (MMD3).

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  • The positive bands, detected using an antibody to dysferlin, confirm equal protein loading in each lane. doi: 10.1371/journal. pone.0008647.g001

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  • DYSF exons were missing have been described, suggesting that internally deleted dysferlin proteins can be functional.

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  • French Canadian cases were found to develop proximal limb girdle muscular dystrophy, usually in their 30s, while European cases developed a more distal non-dysferlin Miyoshi Myopathy (MMD3).

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  • This approach may also be applicable to limb-girdle muscular dystrophy type 2B (LGMD2B), Myoshi myopathy (MM) and distal myopathy with anterior tibial onset (DMAT), which are caused by mutations in the dysferlin-encoding

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  • They failed to detect different levels of relevant muscle proteins including dystroglycans, sarcoglycans, dysferlin, and calpain (data not shown).

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  • In this Paper of the Week, Chuanxi Cai and colleagues demonstrate that mitsugumin 53 (MG53), a muscle-specific TRIM family protein, forms a molecular complex along with dysferlin and Cav3, bringing all three repair proteins together; Cav3 mutations resulting in retention of Cav3 in the Golgi resulted in aberrant localization of MG53 and dysferlin and subsequent defects in membrane repair.

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  • Two proteins involved in membrane repair are dysferlin and caveolin-3, but their interactions, if any, are not yet known.

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  • Insufficient membrane fusion in dysferlin-deficient muscle fibers after heavy-ion irradiation.

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