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- n. An imbalance or other breakdown of a homeostasis system
Sorry, no etymologies found.
Results: 27-OHC dose-dependently increased Abeta peptide production, increased levels of ER stress specific markers caspase 12 and gadd153 (also called CHOP), reduced mitochondrial membrane potential, triggered Ca2+ dyshomeostasis, increased levels of the nuclear factor kappaB (NFkappaB) and heme-oxygenase 1 (HO-1), two proteins activated by oxidative stress.
The researchers concluded "These results show a positive correlation between high fat diet, glucose dyshomeostasis, oxidative stress and DNA damage."
The current study was intended to evaluate the effects of fat intake on glucose dyshomeostasis and DNA injury in rats.
Understanding the mechanism (s) by which CD leads to reduced neuronal storage may provide important new opportunities for treatment of NPC and related neurodegenerative diseases characterized by cholesterol dyshomeostasis.