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- n. A condition in which there is a much reduced amount of myelin in nervous tissue
Sorry, no etymologies found.
SPECT scans indentify blood flow abnormalities consistent with microvascular defects consistent with loss of glial cell energetic metabolic support of neurotransmitters, myelinated neuron action potentials and proper neural network cortical to cortical learning and motor, sensory and abstract concept processing functions. fMRI Functional MRI can demonstrate abnormal myelination and neural pathway functioning with changes in neural traffic and dysmyelination patterns that can be verified on T2 Weighted MRI.
The qkv mice harbor an enhancer/promoter deletion that prevents the expression of isoforms QKI-6 and QKI-7 in myelinating cells resulting in a dysmyelination phenotype.
Li Z, Zhang Y, Li D, Feng Y (2000) Destabilization and mislocalization of the myelin basic protein mRNAs in quaking dysmyelination lacking the Qk1 RNA-binding proteins.
QKI-6 and QKI-7 promote cell cycle arrest of Schwann cells quaking viable mice (qkv) exhibit PNS dysmyelination qkv mice.
It is thought that the lack of QKI-6 and QKI-7 expression is the reason for oligodendrocyte maturation defects and the dysmyelination, observed in.