Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • noun A large structural protein found in small amounts in the plasma membranes of muscle fibers. The absence of dystrophin due to a genetic mutation causes Duchenne's muscular dystrophy; insufficient dystrophin causes Becker muscular dystrophy.

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun biochemistry A cytoplasmic structural protein that is deficient in some forms of muscular dystrophy

Etymologies

from The American Heritage® Dictionary of the English Language, 4th Edition

[dystroph(y) + –in.]

from Wiktionary, Creative Commons Attribution/Share-Alike License

dystrophy +‎ -in

Examples

  • •It is caused by an absence of a protein called dystrophin, which helps to keep the cells found in muscles intact.

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  • In muscular dystrophy, the loss of a protein called dystrophin causes the muscle to literally tear itself apart, a process that cannot be repaired without cell-based intervention.

    PhysOrg.com - latest science and technology news stories

  • This study is a Phase 2b, multicenter, randomized, double-blind, placebo-controlled, dose-ranging, efficacy and safety study, designed to document the clinical benefit of PTC124 when administered as therapy of patients with DMD/BMD due to a nonsense mutation (premature stop codon) in the dystrophin gene.

    Neuromuscular Disorder Research Studies, Clinical Trials

  • The large gene for, say, dystrophin, the muscle-tissue protein that is linked to muscular dystrophy, contains about two million base pairs, or letters, of DNA.

    Vaccinating Against Cancer

  • Duchenne Muscular Dystrophy is characterized by a loss of the protein dystrophin, leading to progressive muscle weakness and wasting through a complex cascade that involves impaired calcium homeostasis, mitochondrial dysfunction and oxidative stress.

    Reuters: Press Release

  • Torrente Y, Belicchi M, Sampaolesi M, Pisati F, Meregalli M, et al. (2004) Human circulating AC133 (+) stem cells restore dystrophin expression and ameliorate function in dystrophic skeletal muscle.

    PLoS ONE Alerts: New Articles

  • Professor Tremblay's team partnered with Cellectis, a French firm specializing in genome engineering, in order to design enzymes-called meganucleases-with the ability to correct the dystrophin gene.

    Medindia Health News

  • Professor Tremblay's team partnered with Cellectis, a French firm specializing in genome engineering, in order to design enzymes-called meganucleases-with the ability to correct the dystrophin gene.

    Medindia Health News

  • The effect of PRO044 will be assessed at the RNA level, to demonstrate specific exon 44 skipping, and at the protein level, to demonstrate novel dystrophin expression in muscle biopsies.

    BioSpace.com Featured News and Stories

  • The effect of PRO044 will be assessed at the RNA level, to demonstrate specific exon 44 skipping, and at the protein level, to demonstrate novel dystrophin expression in muscle biopsies.

    BioSpace.com Featured News and Stories

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