from Wiktionary, Creative Commons Attribution/Share-Alike License.
- adjective Of or pertaining to the
from Wiktionary, Creative Commons Attribution/Share-Alike License
Safety was evaluated by measuring the effect on the viability of vaginal flora, PBMCs, epithelial cells, and ectocervical and colorectal explant tissues.
Additionally, polarized ectocervical and colorectal explant cultures were treated apically with either gel.
Infection was assessed by measuring p24 by ELISA on collected supernatants and immunohistochemistry for ectocervical explants.
Permeability through ectocervical tissue was variable but in all cases the receptor compartment drug concentration reached levels that inhibit HIV-1 infection in vitro.
A transient reduction in epithelial monolayer integrity and epithelial fracture for ectocervical and colorectal explants was noted and likely due to the hyperosmolar nature of the formulation.