from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun medicine A form of
chemotherapyin which the permeabilityof tissue cells is increased by use of an electricpulse
from Wiktionary, Creative Commons Attribution/Share-Alike License
In this paper, we present the first case of deep-seated tumor electrochemotherapy based on numerical treatment planning.
A partial response of the tumor to electrochemotherapy was obtained.
Therefore, according to the calculations, a small volume of tumor cells remained viable after electrochemotherapy, and these were sufficient for tumor regrowth.
In this, the first reported clinical case, deep-seated melanoma metastasis in the thigh of the patient was treated by electrochemotherapy, according to a treatment plan obtained by numerical modeling and optimization.
Histologically, the metastasis showed partial necrosis due to electrochemotherapy, estimated to represent 40-50% of the tumor.
During the procedure, the four electrode treatment plan was adopted and the patient was treated accordingly by electrochemotherapy with bleomycin.
Although only a partial response was obtained, the presented work demonstrates that treatment of deep-seated tumor nodules by electrochemotherapy is feasible and sets the ground for numerical treatment planning-based electrochemotherapy.