Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A drug that triggers apoptosis in cancer cells.

Etymologies

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Examples

  • Synta is expected to present data from its Phase 3 elesclomol study Symmetry during mid-2009, according to Susquehanna Financial Group.

    Options Traders Circle Drug Firms

  • Separately, Synta Pharmaceuticals Corp. said Monday that a cancer-drug venture involving Glaxo and elesclomol would end within 90 days, putting the treatment further into question after a late-stage trial was stopped earlier this year amid mortality concerns.

    Glaxo Seals

  • This was the case in the elesclomol and AS404 studies, which showed an impressive numeric difference in OS which was not statistically significant.

  • Synta Pharmaceuticals Corp. said Tuesday it will restart development of its skin cancer drug candidate elesclomol.

    D Mag - News

  • In patients with normal LDH levels, study data show a combination of elesclomol and the chemotherapy drug paclitaxel was significantly more effective than paclitaxel alone, Synta said.

    D Mag - News

  • Research on elesclomol in skin cancer was stopped in February 2009 because of unexpected numbers of deaths among test subjects who took the drug.

    D Mag - News

  • Earlier research shows that elesclomol helped extend the lives of patients with normal LDH levels but did not work as well on patients with high LDH levels.

    D Mag - News

  • The company said patients with high LDH have lower oxygen levels, which changes the metabolism of cancer cells and reduces the effectiveness of elesclomol.

    D Mag - News

  • The company later said elesclomol did not meet its goal in the trial.

    D Mag - News

  • Phase 1 trials of STA-9090 in solid tumors, as well as 12 month updated survival results from the SYMMETRY trial of elesclomol in metastatic melanoma, were presented at the 2010 Annual

    American Chronicle

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