Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Within cartilage

from the GNU version of the Collaborative International Dictionary of English

  • adj. Growing or developing within cartilage; -- applied esp. to developing bone.

from The Century Dictionary and Cyclopedia

  • Situated within a cartilage.

Etymologies

Sorry, no etymologies found.

Examples

  • Campos-Xavier AB, Martinet D, Bateman J, Belluoccio D, Rowley L, et al. (2009) Mutations in the heparan-sulfate proteoglycan glypican 6 (GPC6) impair endochondral ossification and cause recessive omodysplasia.

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  • Hoenselaar KD, Gillespie JR, Beier F (2008) The PI3K pathway regulates endochondral bone growth through control of hypertrophic chondrocyte differentiation.

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  • In a previous publication we showed that pharmacological inhibition of the PI3K signaling pathway results in reduced endochondral bone growth, and in particular, shortening of the hypertrophic zone in a tibia organ culture system.

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  • Agoston H, Khan S, James CG, Gillespie JR, Serra R, et al. (2007) C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and - independent pathways.

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  • Ulici V, Tuckermann J, Underhill TM, Beier F (2007) Expression profiling of Dexamethasone-treated primary chondrocytes identifies targets of glucocorticoid signalling in endochondral bone development.

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  • Long bones, such as tibia, grow and elongate through the process of endochondral ossification where skeletal elements are first laid down as cartilage precursors and then this cartilage is replaced by bone

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  • (BMPs), Wnts, and Ihh, all of which are important for osteogenesis, as well as RANKL and VEGF, which promote osteoclast activation and vascular invasion Hypertrophic differentiation is not only an essential step in endochondral ossification, but it also seems to be a pathological event in early osteoarthritis.

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  • Chung UI (2004) Essential role of hypertrophic chondrocytes in endochondral bone development.

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  • A defect in the endochondral ossification process at the joint surface causes displacement of an area of abnormal cartilage as a fragment or flap (this condition is termed osteochondritis dissecans), or as a cyst that remains just beneath the surface of the joint.

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  • Mammalian skeletal development is controlled by two mechanisms, endochondral and intramembranous bone formation.

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