Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Of or pertaining to an endolysosome

Etymologies

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Examples

  • With the data of the present report, however, endolysosomal membranes can now potentially be included in regulatory activity mediated by Irgm1.

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  • In future analyses it should be borne in mind that tagging of Irgm1 leads to loss of Golgi localisation and enhanced localisation on endolysosomal membranes, probably as a result of constitutive activation.

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  • The targeting motif known to be required for Golgi localisation is surprisingly also required for endolysosomal localisation.

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  • However, unlike Golgi localisation, localisation to the endolysosomal system also requires the functional integrity of the nucleotide binding site, and thus probably reflects transient activation.

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  • Irgm1 is the first IRG protein to be found associated with the endolysosomal membrane system in addition to either Golgi (Irgm1 and Irgm2) or ER (Irgm3) membranes, and we interpret the result to be in favour of a regulatory function of IRGM proteins at cellular membrane systems.

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  • Golgi localisation is lost when Irgm1 is tagged at either N - or C-termini with EGFP, while localisation to the endolysosomal system is relatively favoured.

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  • Irgm1 has thus a constitutive association with the endolysosomal membrane system in addition to the Golgi apparatus, a unique property among IRG proteins tested so far.

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  • Fischer R, Bachle D, Fotin-Mleczek M, Jung G, Kalbacher H, et al. (2006) A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway.

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