Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. any hereditary characteristic that is normally associated with some condition but is not a direct symptom of that condition.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

endo- +‎ phenotype

Examples

  • This comes at a time when psychiatry is looking beyond the current diagnostic manuals as the sole definition of mental disorder, and considering the concept of the 'endophenotype' - measurable aspects of biology thought to be the key underlying components that increase risk for mental disorder.

    Mind Hacks: Brain scans, mental illness and false promises

  • Link to academic paper on the 'endophenotype' concept.

    Mind Hacks: Brain scans, mental illness and false promises

  • Yes, the genetics of it are complicated, it's an area of interest viz work for me, but I think the point I was trying to make was more along the lines of how genetics interacts with human culture and history and nurture (the latter leading to the 'endophenotype') to produce selection that isn't the straightforward natural selection process in the wild - of survival of the fitest in the wild.

    Articles

  • Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism.

    Autism Research: Breakthrough Discovery on the Causes of Autism

  • Chen P, Jou YS, Fann CS, Chen JW, Chung CM, et al. (2009) Lipoprotein lipase variants associated with an endophenotype of hypertension: hypertension combined with elevated triglycerides.

    PLoS ONE Alerts: New Articles

  • Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, et al. (2007) Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype.

    PLoS ONE Alerts: New Articles

  • The McGirr and colleagues study is the most explicit and comprehensive examination of impulsive aggression as a putative endophenotype for suicidal behavior yet reported.

    Am J Psychiatry current issue

  • One candidate endophenotype for suicidal behavior is the trait of "impulsive aggression," which may be defined as the tendency to respond to provocation or frustration with hostility or aggression.

    Am J Psychiatry current issue

  • B traits, and mediation of familial transmission of suicidal behavior via the transmission of the trait of impulsive aggression that can be raised about impulsive aggression as an endophenotype for suicidal behavior.

    Am J Psychiatry current issue

  • Gottesman II, Gould TD: The endophenotype concept in psychiatry: etymology and strategic intentions.

    Am J Psychiatry current issue

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