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Intracellular antibodies expressed and retained inside the endoplasmatic reticulum
We also observed a relative paucity of proteins from the mitochondria, ribosomes, endoplasmatic reticulum and lysosomes among phosphorylated proteins.
Recent data suggest that GRP78, a major endoplasmatic chaperone protein, may be critical for tumor angiogenesis, and its overexpression may protect cancer cells from apoptosis, thereby promoting metastasis and chemoresistance.
Western blot analyses representative of two independent experiments with similar results are shown. doi: 10.1371/journal. pone.0011772.g003 bcl-2 protein interacts with HIF-1α protein in the nucleoplasm bcl-2 is primarily localized in the outer mitochondrial membrane with minor expression in the nucleus and in the endoplasmatic reticulum
The "modified mitochondria" are found in the cytoplasm of the cell and are surrounded by 1-2 cisterns of rough endoplasmatic reticulum, just as the mitochondria of certain related aerobic heterolobosea.