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Examples
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TEM1/endosialin is an emerging microvascular marker of tumor angiogenesis.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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Vascular Tem1/endosialin was induced in intracranial U87MG GBM xenografts grown in mice.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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Although lack of TEM1/endosialin did not suppress growth of intracranial GBM xenografts, it did increase tumor vascularity.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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The cellular localization of TEM1/endosialin and its expression profile in primary and metastatic brain tumors support efforts to therapeutically target this protein, potentially via antibody mediated drug delivery strategies.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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In situ hybridization (ISH), immunohistochemistry (IH) and immunofluorescence (IF) were used to localize TEM1/endosialin expression in grade II-IV astrocytomas and metastatic brain tumors on tissue microarrays.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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We characterized the expression pattern of TEM1/endosialin in astrocytic and metastatic brain tumors and investigated its role as a therapeutic target in human endothelial cells and mouse xenograft models.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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TEM1/endosialin was upregulated in primary and metastatic human brain tumors, where it localized primarily to the tumor vasculature and a subset of tumor stromal cells.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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Tem1/endosialin KO vs WT mice demonstrated equivalent survival and tumor growth when implanted with intracranial GBM xenografts, although Tem1/endosialin KO tumors were significantly more vascular than the WT counterparts.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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Intracranial U87MG glioblastoma (GBM) xenografts were analyzed in nude TEM1/endosialin knockout (KO) and wildtype (WT) mice.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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TEM1/endosialin showed limited co-localization with CD31, alphaSMA and fibronectin in clinical specimens.
BioMed Central - Latest articles Eleanor Carson-Walter 2009
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