endosomes

RPM-1 is thought to positively regulate a Rab GTPase pathway to promote vesicular trafficking via late endosomes, which is critical for the organization of presynaptic terminals.

PLoS ONE Alerts: New Articles 2009

Using a membrane-specific probe that labels endosomes and lysosomes and fluorescein-labeled annexin 5 that labels

Journal of Biological Chemistry current issue Mirnikjoo, B., Balasubramanian, K., Schroit, A. J. 2009

Complicating these efforts is the fact that BACE1 seems to cleave APP in vesicles called endosomes, which sport a pH much more acidic than that of other areas of the cell or the extracellular fluid.

innovations-report 2008

Loss of GlcNAcT-IVa, or the addition of glycan-ligand mimetics, attenuates Glut-2 cell-surface half-life, provoking endocytosis with redistribution into endosomes and lysosomes.

“I have vision, and the rest of the world wears bifocals.”* | The Blog of Michael R. Eades, M.D. 2006

From the above experiments it is not clear if cycling of CXCR7 from the plasma membrane to endosomes is ligand induced or may also occur constitutively.

PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010

Incubation of the slices with 200 nM CXCL12-Venus causes the appearance of fluorescent endosomes, suggesting the uptake of the chemokines by surface receptors (upper right).

PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010

Importantly, in HEK-293 cells, PAT1 is highly concentrated in intracellular compartments, including endosomes, wherein mTOR shuttles upon amino-acid stimulation.

Naturejobs - All Jobs S Heublein 2010

Frozen sections of the hearts reveal endosomes in valve endothelial cells loaded with CXCL12-mCherry.

PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010

However, the detailed mechanism by which the full-length receptors embedded in the endosomal membrane travel all the way from the cell surface to the early endosomes and pass through the nuclear pore complexes is unknown.

Naturejobs - All Jobs Y-N Wang 2010

From the above experiments it is not clear if cycling of CXCR7 from the plasma membrane to endosomes is ligand induced or may also occur constitutively.

PLoS ONE Alerts: New Articles Ulrike Naumann et al. 2010

Endosomes are a highly dynamic network of vesicles that sit under the cell membrane and aid lysosomes.

What Causes Alzheimer’s? Scientists Are Rethinking the Answer. | Quanta Magazine Yasemin Saplakoglu 2022