Definitions

from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A protein which inhibits the formation of the blood vessels that supply tumours.

Etymologies

endo(thelial) + -stat + -in.
(American Heritage® Dictionary of the English Language, Fourth Edition)

Examples

  • We have also shown that anti-angiogenic factors, such as endostatin, counteract proangiogenic effects in the eye (

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  • But endostatin, under study at the Dana-Farber Cancer Institute in Boston, the M.D.

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  • Even people like Duane Gay, one of the first humans to be treated with endostatin, knows that the drug may not save him.

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  • At least 20 drugs called angiogenesis inhibitors are now in clinical trials, including angiostatin and endostatin, the compounds isolated by Dr. Michael O'Reilly in Folkman's lab.

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  • And sophisticated imaging showed that as doses of endostatin increased, blood flow to tumors decreased in some patients -- the goal of angiogenesis inhibitors.

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  • Simcere declares itself a maker of branded generic drugs, though it also makes the innovative cancer treatment Endu, a recombinant human endostatin and the stroke treatment edaravone.

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  • Structural analysis of the NC1 domain of collagen XVIII suggests that it consists of three segments, an N-terminal trimerization domain implicated in self-assembly of homotrimers; a central protease-sensitive hinge region; and the compact C-terminal endostatin domain

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  • The popularity of the idea waned in the early 2000s following disappointing results in clinical trials of two anti-angiogenic compounds, angiostatin and endostatin, that were discovered in Folkman's lab.

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  • Javaherian K, Lo KM, Chopra R, Boehm T, et al. (1998) Zinc-dependent dimers observed in crystals of human endostatin.

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  • At the request of the SFDA, Simcere initiated a Phase IV clinical study to further validate the safety and therapeutic efficacy of Endu, a modified version of recombinant human endostatin, in combination with platinum-based chemotherapy, on large samples of patients in advanced stages of non-small cell lung cancer (NSCLC).

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