Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of bacterial products characterized by nine- or ten-membered rings containing two triple bonds separated by a double bond, many of which are highly toxic to DNA and used as antitumour agents.

Etymologies

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Examples

  • To test this hypothesis, we first synthesized several aromatic enediyne derivatives

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  • In a recent study Jones et al. examined the viability of proteins as targets of thermally and photo-activated enediyne derivatives and confirmed at the molecular level.

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  • The table shows the IC50 values for inhibition of recombinant proprotein convertases furin, PC5 and PC7 by various aromatic enediyne compounds.

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  • Among the compounds tested, a 12-membered 1, 4-diaza enediyne heterocyclic ring compound with bis-benzyl substituent (AB-2) has been found to exhibit highest inhibitory activities against both furin and PC7 with IC

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  • Kar M, Mandal S (2005) Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design.

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  • This is the first report of PC-inhibitory activity of an enediyne compound

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  • They have shown that specifically designed enediyne derivatives can degrade proteins under suitable conditions

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  • Most aromatic enediyne compounds are chemically highly reactive and can easily generate upon heating reactive bis-radical species

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  • Except for minor protease activating effect of AB-3 towards PC7, all other enediyne compounds exhibited inhibitory effects towards furin, PC5 and PC7 with IC

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  • Due to this unique ability to cyclize and produce reactive bis-radicals, several enediyne derivatives have been designed as reactive species especially for DNA degradation

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