enediynyl

Khatib AM, Mohottalage D, Basak S, Kolajova M, et al. (2009) A novel enediynyl peptide inhibitor of furin that blocks processing of proPDGF-A, B and proVEGF-C.

PLoS ONE Alerts: New Articles Katarina Hajdin et al. 2010

Thus we prepared a novel enediynyl peptide using a combination of organic and peptide chemistry and demonstrated its potent furin inhibitory activity both in vitro and cellular models.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Scheme for chemical synthesis of Fmoc protected enediynyl amino acid (Eda).

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Rudra KR, Bag SS, Basak A (2002) Synthesis, reactivity and conformational preferences of novel enediynyl peptides: a possible scaffold for β-sheet capping turns.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Design of β-turn mimetic furin inhibitor based on enediynyl amino acid (Eda) and profurin 98-112.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Herein, we report, for the first time, the synthesis and biological evaluation of a newly designed potent furin inhibitor that contains a highly reactive beta-turn inducing and radical generating "enediynyl amino acid" (Eda) moiety.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Mandal S, Das AK, Bertolasi V (2002) Benzene fused monocyclic enediynyl amides: synthesis, reactivity and DNA-cleavage activity in comparison to the corresponding sulfonamides.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

However while this manuscript is under review, the inhibition of chymotrypsin by an enediynyl peptide was reported in the literature

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Herein, we report, for the first time, the synthesis and biological evaluation of a newly designed potent furin inhibitor that contains a highly reactive beta-turn inducing and radical generating "enediynyl amino acid" (Eda) moiety.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009

Our approach was primarily based on a specially constructed unnatural amino acid called "Eda or enediynyl amino acid" and its incorporation at the cleavage site of prodomain sequence of furin whose primary role is to regulate the protease activity by providing proper folding after binding.

PLoS ONE Alerts: New Articles Ajoy Basak et al. 2009