Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any of a class of enzymes that degrade endogenous enkephalin opioid peptides.

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

enkephalin +‎ -ase

Examples

  • This latter, which is the most important of the three, has been given the name enkephalinase.

    Alcohol and The Addictive Brain

  • Protecting enkephalin supplies by preventing their destruction by enkephalinase reduces voluntary alcohol intake in alcohol-preferring animals.

    Alcohol and The Addictive Brain

  • The positive nature of the results merits further investigation and full-scale clinical testing of the concepts of amino acid loading and enkephalinase inhibition.

    Alcohol and The Addictive Brain

  • In a series of experiments they demonstrated the ability of D-phenylalanine to inhibit enkephalinase, resulting in a long-term painkilling effect in both animals and humans.

    Alcohol and The Addictive Brain

  • Because of multiple causes acting to distort reward, we had chosen to use the “amino acid loading technique” in our formula, combining key amino acids with an enkephalinase inhibitor with the goal of offsetting a wide range of neurotransmitter deficiencies.

    Alcohol and The Addictive Brain

  • This finding was later confirmed by Larry Grupp and associates at the University of Toronto when they showed that other types of enkephalinase inhibitors also reduce alcohol intake in rats.2

    Alcohol and The Addictive Brain

  • D-phenylalanine, to inhibit enkephalinase, the enzyme that metabolizes or breaks down enkephalin, thereby increasing the availability of enkephalin and, presumably, making more dopamine available at the reward sites.

    Alcohol and The Addictive Brain

  • Over the next 18 days, we injected the alcohol-preferring mice with the enkephalinase inhibitor D-phenylalanine, and the water-preferring mice with a saline solution, then retested their one-day alcohol consumption.

    Alcohol and The Addictive Brain

  • The amount of enkephalinase, the enzyme that metabolizes enkephalin, increases, thereby reducing the supply of this opioid at the synapse.

    Alcohol and The Addictive Brain

  • De Witte, Kelatorphan, a potent enkephalinase inhibitor, presents opposite properties when injected intracerebroventricularIy or into the nucleus accumbens on intracranial self-stimulation, Neurochemistry International, 12 1988: 347-50.

    Alcohol and The Addictive Brain

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