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The plant lignans secoisolariciresinol diglucoside SDG, matairesinol, and pinoresinol in flaxseeds are converted in the colon of humans and other animals into the mammalian lignans enterodiol and enterolactone, which are more potent phytoestrogens than plant lignans.
Compounds such as genistein, naringenin, kaempferol, and lignans such as enterodiol and enterolactone, were not linked to increased incidence of adverse events, according to an analysis of 92 randomised controlled trials with almost 10,000 participants published in