enthalpic

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects).

Citizendium, the Citizens' Compendium - Recent changes [en] 2009

A new approach to drug development (labeled SAR by NMR) has been developed based on the ability to detect the weak binding of fragments using NMR spectroscopic chemical shift changes; subsequently the fragments identified to bind weakly at separate sites on the receptor can be joined together using an inert linker and the resulting compound would be expected to bind much more strongly than either fragment (due to entropic and additive enthalpic effects). drugs with stable isotope labels may be used to monitor the rate of dissolution of an administered drug, to monitor is absorption, distribution and elimination and also to identify the products into which it is transformed.

Citizendium, the Citizens' Compendium - Recent changes [en] 2009