Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. chemokine

Etymologies

Sorry, no etymologies found.

Examples

  • Their recruitment to inflammatory sites occurs in response to chemotactic and activation signals, such as eotaxin and interleukin-5, and is a tightly controlled process.

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  • Irrespective of its source (milk or neutrophil derived), LTF inhibits eotaxin-stimulated eosinophil migration with no effects on eosinophil viability.

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  • A recent analysis of inflammatory markers in MDD patients using a cytokine panel has confirmed the elevation of pro-inflammatory interleukins and highlighted abnormalities in additional factors, such as MIP-1 and eotaxin, not previously implicated in MDD

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  • In the report, scientists from Queen's University of Belfast, University of Oxford and Trinity College Dublin show for the first time that eotaxin, a chemical that helps immune cells locate the site of infection, blocks basic "fighter" cells from transforming into

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  • "Our study reveals a new role for the chemokine eotaxin in controlling immune cell types at the site of allergic reaction," said Nigel Stevenson, a researcher involved in the study.

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  • Then the researchers mimicked what occurs during an allergic reaction by treating the cells with eotaxin, which was previously believed to only attract immune cells during an allergic reaction.

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  • Through a series of laboratory procedures, they tracked changes in immune cell type and found that eotaxin inhibits monocytes becoming dendritic cells (that find foreign invaders so other immune cells can neutralize them), resulting in more "fighter" cells being present during an allergic response.

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  • This discovery shows how and why eotaxin plays an important role in the severity of allergic reactions and may be a target for an entirely new class of allergy medications.

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  • "The insights from this work on the unexpected role of eotaxin should provide novel therapeutic opportunities for intervention during diseases like asthma, food allergies and other situations where unchecked allergic responses cause problems."

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  • Research published in the Journal of Leukocyte Biology identifies eotaxin as a novel drug target

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