Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Plural form of ephrin.

Etymologies

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Examples

  • "Normally ephrins cause growth cones to collapse in neurons, but in tuberous sclerosis the axons don't heed these repulsive cues, so keep growing," says Sahin.

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  • Next the researchers found activation of a molecular pathway called mTOR that occurred in response to loss of responsiveness of ephrins.

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  • Further investigation showed that the axons 'tips, known as "growth cones," did not respond to navigation cues from a group of molecules called ephrins.

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  • There is actually considerable overlap between the axon guidance and ephrin signaling pathways with ephrins along with netrins, slits and semaphorins being the main families of guidance molecules in the developing nervous system

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  • Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins.

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  • With some evidences, it is also suggested that endocytosis is a critical step for turning the interaction of ephrins and Ephs from contact into repulsion efficiently

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  • Both Eph receptor tyrosine kinases and ephrins, high-affinity ligands of Ephs, are membrane proteins.

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  • Alternatively, because structurally similar ephrins are expressed in muscles, they might compensate the phenotype after birth.

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  • It is noteworthy that the expression of ephrins, Ephs, and Meltrin β in the NMJ is sustained in adult mice, implying that these molecules are also important in the maintenance of the NMJ.

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  • The localized expression of these ephrins and Ephs at the NMJ suggests that they also function at the interface between motor neurons and muscles during late stages of development and / or in adult for the formation or maintenance of the NMJ.

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