ephrins

"Normally ephrins cause growth cones to collapse in neurons, but in tuberous sclerosis the axons don't heed these repulsive cues, so keep growing," says Sahin.

Emaxhealth 2010

Further investigation showed that the axons 'tips, known as "growth cones," did not respond to navigation cues from a group of molecules called ephrins.

Medlogs - Recent stories 2010

Next the researchers found activation of a molecular pathway called mTOR that occurred in response to loss of responsiveness of ephrins.

Emaxhealth 2010

"Normally ephrins cause growth cones to collapse in neurons, but in tuberous sclerosis the axons don't heed these repulsive cues, so keep growing," says Sahin.

Emaxhealth 2010

Further investigation showed that the axons 'tips, known as "growth cones," did not respond to navigation cues from a group of molecules called ephrins.

Medlogs - Recent stories 2010

Next the researchers found activation of a molecular pathway called mTOR that occurred in response to loss of responsiveness of ephrins.

Emaxhealth 2010

There is actually considerable overlap between the axon guidance and ephrin signaling pathways with ephrins along with netrins, slits and semaphorins being the main families of guidance molecules in the developing nervous system

PLoS ONE Alerts: New Articles Greg T. Sutherland et al. 2009

Compared with other Eph receptors, EphA4 is distinguished by its ability to bind to both type A ephrins and most type B ephrins.

Medlogs - Recent stories 2008

With some evidences, it is also suggested that endocytosis is a critical step for turning the interaction of ephrins and Ephs from contact into repulsion efficiently

PLoS ONE Alerts: New Articles 2008

Both Eph receptor tyrosine kinases and ephrins, high-affinity ligands of Ephs, are membrane proteins.

PLoS ONE Alerts: New Articles 2008