Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Plural form of episome.
Etymologies
Sorry, no etymologies found.
Examples
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SV40 DNA could be detected in the offspring but it was impossible to demonstrate with certainty whether the DNA was integrated into the host genome, or remained as episomes [25].
The 2007 Nobel Prize in Physiology or Medicine - Advanced Information
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Bold lines represent yeast chromosomes; circles represent yeast episomes. doi: 10.1371/journal. pone.0010472.g002
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The strategy of these authors entailed the introduction of a polycistronic vector encoding the genes c-Myc, Klf4, and SV40LT and selection of stable episomes that provided persistent gene expression to achieve reprogramming followed by the identification of vector-free subclones after several passages in the absence of selection.
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"The plasmids carry all the needed transgenes, but don't integrate into the host DNA, they just float around as episomes" in the cell, Thomson says.
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"Once the transgenes have done their job and are no longer needed, one can merely recover induced pluripotent stem cells that have lost their episomes."
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