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- n. Plural form of epithelialization.
Sorry, no etymologies found.
The subcellular mechanisms of TGF-β1 are crucially important to understanding its functions in re-epithelialisation and effective research tools are needed due to the limitations of current biological models
As well as the auto-regulation mechanism, the influence of the ECM matrix and of TGF-β1 on cell proliferation were simulated expilicitly, while the influence of other factors on cell proliferation were modelled implicitly in the re-epithelialisation model.
In the 3D model of the epidermis (which will also be referred to as the re-epithelialisation model in the second part of this paper), there are attractive and repelling forces between different agents as in the previous model.
In normal human epidermis, relatively low levels of TGF-β1 are expressed predominantly in the suprabasal, differentiating layers, suggesting it may have a role in maintaining the cessation of growth in the differentiating cells of epidermis During re-epithelialisation, the expression of TGF-β1 is induced by various ECM components.
The extensive in vitro and in vivo experimental literature describing its actions nevertheless describe an apparent paradox in that during re-epithelialisation it acts as proliferation inhibitor for keratinocytes.
In this research, extensive literature of TGF-β1 synthesis, expression, secretion, activation, signalling and function during re-epithelialisation were analysed carefully.
The agents 'rule set which now embed TGF-β1 functions and the biochemical equations used in COPASI were based on the analysis of qualitative or semi-quantitative biological data about TGF-β1 synthesis, expression, activation, signaling and biological functions during re-epithelialisation.