from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A drug, C24H30O6, that blocks aldosterone receptors and is used to treat hypertension and congestive heart failure.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
aldosterone antagonistused as an adjunctin the management of chronic heart failure.
from The American Heritage® Dictionary of the English Language, 4th Edition
An old drug called spironolactone and a newer one called eplerenone can lower mortality for patients with severe heart failure, but they can also cause dangerous elevations in potassium levels.
According to Healthline. com, "This medicine may also interact with the following medications: antacids containing aluminum, magnesium, or calcium; aspirin and aspirin-like medicines; cyclosporine; diuretics; eplerenone; medicines for blood pressure like captopril, enalapril, lisinopril; potassium supplements, salt substitutes, or low-salt milk; vitamin D supplements."
The two aldosterone antagonists currently licensed for commercial use in the U. S are spironolactone and eplerenone.
The ongoing studies, are TOPCAT comparing spironolactone (45mg) versus placebo in 4500 patients with mild HF (NYHA II, EF > 45%) and preserved LV function; and EMPHASIS HF, looking at use of the aldosterone antagonist eplerenone in patients with mild heart failure (NYHA II, Ejection Fraction < 30%) and systolic dysfunction.
Aldosterone antagonists: This category, which includes spironolactone and eplerenone, removes sodium and water from the bloodstream.