Definitions
from The American Heritage® Dictionary of the English Language, 5th Edition.
- noun A drug, C24H30O6, that blocks aldosterone receptors and is used to treat hypertension and congestive heart failure.
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun An
aldosterone antagonist used as anadjunct in the management ofchronic heart failure .
Etymologies
from The American Heritage® Dictionary of the English Language, 4th Edition
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Examples
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An old drug called spironolactone and a newer one called eplerenone can lower mortality for patients with severe heart failure, but they can also cause dangerous elevations in potassium levels.
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According to Healthline. com, "This medicine may also interact with the following medications: antacids containing aluminum, magnesium, or calcium; aspirin and aspirin-like medicines; cyclosporine; diuretics; eplerenone; medicines for blood pressure like captopril, enalapril, lisinopril; potassium supplements, salt substitutes, or low-salt milk; vitamin D supplements."
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The two aldosterone antagonists currently licensed for commercial use in the U. S are spironolactone and eplerenone.
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The ongoing studies, are TOPCAT comparing spironolactone (45mg) versus placebo in 4500 patients with mild HF (NYHA II, EF > 45%) and preserved LV function; and EMPHASIS HF, looking at use of the aldosterone antagonist eplerenone in patients with mild heart failure (NYHA II, Ejection Fraction < 30%) and systolic dysfunction.
PhysOrg.com - latest science and technology news stories 2009
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Aldosterone antagonists: This category, which includes spironolactone and eplerenone, removes sodium and water from the bloodstream.
Medindia Health News 2009
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