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Examples
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Therefore, three proteasomal inhibitors, MG132, clasto-lactacystin β-lactone and epoxomicin, were tested for their ability to suppress the ENC1-induced decrease in Nrf2 expression.
PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009
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Amongst all proteasome inhibitors tested, epoxomicin showed the highest activity in chloroquine-susceptible (IC50: 6.8 nM [3D7], 1.7 nM [D10]) and in chloroquine-resistant laboratory strains (IC50: 10.4 nM [Dd2]) as well as in field isolates (IC50: 8.5 nM).
BioMed Central - Latest articles Peter G Kremsner and Benjamin Andrea Kreidenweiss 2008
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The peptide alpha ', beta'-epoxyketone epoxomicin is highly active against P. falciparum regardless the grade of the parasite's chloroquine susceptibility.
BioMed Central - Latest articles Peter G Kremsner and Benjamin Andrea Kreidenweiss 2008
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HEK cells were treated for 6-16 h with the β-secretase inhibitor C3 (3 μM, BACE inhibitor IV) or the metalloprotease inhibitor GM6001 (15 μM), or for 6 h with the proteasome inhibitor epoxomicin (1 μM) or phorbol 12-myristate 13-acetate (PMA, 0.5 μM).
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Transfected cells were treated with proteasome inhibitors MG132 (M) (10 µM), clasto-lactacystin β-lactone (Lac) (10 µM) or epoxomicin (Ep) (1 µM), or lysosome inhibitors chloroquine (Ch) (50 µM) or ammonium chloride (Ac) (50 mM) for 4 hr before cells were lysed at
PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009
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Similar levels of induction were observed when clasto-lactacystin β-lactone or epoxomicin was used (
PLoS ONE Alerts: New Articles Xiao-Jun Wang et al. 2009
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The DSG2 ICD was observed when its degradation was prevented by the proteasome inhibitor epoxomicin (
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