from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. A particular narcotic painkiller.
Sorry, no etymologies found.
University of Montana, Missoula, Montana, USA. 120 pp. Conry, P.J. (In press) Immobilizing Malayan gaur with etorphine.
A biologist identifies a 5-ton bull from a helicopter and darts him with enough etorphine, a potent anaesthetic, to, well, knock out an elephant.
The mu-opioid receptor is activated by several ligands including morphine, etorphine and fentanyl.
While morphine effects phosphorylation of the kinase ERK through activation of PKC (protein kinase C), etorphine also activates ERK but by activation of beta-arrestin.
Morphine causes the phosphorylated ERK to stay in the cytoplasm while etorphine causes the ERK to translocate to the nucleus.
Intrigued again by the problem of the opiate receptor site in Goldstein’s paper, Eric Simon designed an experiment focused on an opiate agonist 1,000-10,000 times more powerful than morphine itself etorphine.