from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • adjective Of or pertaining to excitotoxicity
  • adjective Characteristic of an excitotoxin


Sorry, no etymologies found.


  • It also protects nerve cells from the excitotoxic effects of glutamate, aids in energy production within the cells, and helps with glucose metabolism.18

    The Chemistry of Calm

  • The most widely used food ingredients that have excitotoxic activity are monosodium glutamate, aspartame, hydrolyzed vegetable protein, and other additives that stimulate the taste buds and mask the flavor of many processed foods, Fresh, natural foods don't require this form of flavor enhancement.

    Alison Rose Levy: Hold the MSG: Food Triggers for Epilepsy and Other Neurological Illnesses

  • The artificial sweetener, aspartame, marketed as NutraSweet, Equal, and under several other brand names, is one of most widely consumed of the food additives with excitotoxic activity.

    Alison Rose Levy: Hold the MSG: Food Triggers for Epilepsy and Other Neurological Illnesses

  • As to artificial sweeteners, they all have their drawbacks: bitter aftertaste, bloating and gas, excitotoxic potential for the brain and nervous system, allergic reactions, etc.

    Sweeter Than Sugar?

  • The characteristic punctate distribution of GAD65 along neurites of differentiated cultured hippocampal neurons was significantly reduced after excitotoxic injury, and the total GAD activity measured in extracts from the cerebellum or cerebral cortex at 24h postmortem (when there is a partial cleavage of GADs) was also decreased.

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  • Since calpains, a group of calcium activated proteases, play a key role in GAD65/67 cleavage under excitotoxic conditions the results suggest that GADs are cleaved after ubiquitination and degradation of an unknown binding partner by the proteasome.

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  • We found that excitotoxic stimulation of cultured hippocampal neurons with glutamate leads to a time-dependent cleavage of GAD65 and GAD67 in the N-terminal region of the proteins, and decrease the corresponding mRNAs.

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  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators and gene therapy.

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  • The enzyme is cleaved under excitotoxic conditions, but the mechanisms involved and the functional consequences are not fully elucidated.

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  • The results show a role of the UPS in the cleavage of GAD65/67 and point out the deregulation of GADs under excitotoxic conditions, which is likely to affect GABAergic neurotransmission.

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