from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Occurring outside of a gene, or as a result of a different gene


Sorry, no etymologies found.


  • The 3′ and 5′ ends of the genome contain short extragenic sequences known as the 'leader' and

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  • For example, it is now known that the underlying cause of cancer is “chromosomal instability,” or damage to extragenic structures - not mutations to individual genes.

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  • We thus applied this machine-learning algorithm to the dataset of 4,588 extragenic Pol_II peaks described above.

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  • Moreover, extragenic transcription was downregulated when the coding gene reached its maximal level of expression, a result particularly obvious at Cxcl11.

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  • One model supported by experimental data is that extragenic transcription leads to the repeated passage of several

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  • A curated dataset of extragenic Pol_II peaks in mouse macrophages.

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  • A second expected feature of a ripple effect is that extragenic waves of Pol_II should show continuity with Pol_II elongating from the inducible coding gene.

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  • We therefore searched our dataset of 2,236 predicted enhancers associated with extragenic Pol_II for enriched TFBSs.

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  • Pol_II peaks are extremely broad, covering about 20 kb of extragenic sequence with no annotation of known or predicted exons; moreover their height is much lower than that found inside the coding region.

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  • Moreover, much of this extragenic transcription is regulated by stimulation.

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