Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • adj. Outside of the villi

Etymologies

from Wiktionary, Creative Commons Attribution/Share-Alike License

From extra- +‎ villous

Examples

  • This interaction is further complicated by the fact that extravillous trophoblasts, cells of fetal origin, invade and migrate into the maternal tissues and spiral arteries and are found in close contact with maternal immune cells.

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  • Burrows TD, Hiby SE, Bowen JM, Joseph S, et al. (2000) Surface expression of HLA-C antigen by human extravillous trophoblast.

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  • Furthermore, double immunofluorescent staining of placental sections revealed that while the conformed form of HLA-G was expressed in all extravillous trophoblasts, the free heavy chain form of HLA-G was expressed in more distal cells of the column, the invasion front.

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  • This molecule displays many unique features such as low polymorphism, a truncated cytoplasmic tail and restricted distribution to the extravillous cytotrophoblasts

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  • HLA-G is found on the cell surface of extravillous trophoblasts in both the free heavy chain (FHC) form and the B2 microglobulin bound conformed form.

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  • We performed double immunofluorescent staining to determine if there is differential expression of the HLA-G FHC and conformed forms on extravillous trophoblasts.

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  • Hyperglycosylated hCG inhibits apoptosis in extravillous invasive cytotrophoblast cells promoting cell invasion, growth and malignancy.

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  • While regular hCG is made by fused villous syncytiotrophoblast cells, extravillous invasive cytotrophoblast cells make the variant hyperglycosylated hCG.

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  • This variant is an autocrine factor, acting on extravillous invasive cytotrophoblast cells to initiate and control invasion as occurs at implantation of pregnancy and the establishment of hemochorial placentation, and malignancy as occurs in invasive hydatidiform mole and choriocarcinoma.

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