Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun The formation of
fibrils
Etymologies
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Examples
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In vitro fibrillization assays were performed on these five dopamine analogs.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Moreover, the presence (B, C) or absence (E, F) of ThT did not show any effect upon the inhibitory action of DOP on α-syn fibrillization. doi: 10.1371/journal. pone.0009234.g004
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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We observed the kinetics of the fibrillization process and analyzed the reaction end products by AFM to obtain spatially resolved information of their morphology.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Exploiting this fact, we applied an integrated computational and experimental approach to find alternative ligands that might modulate the fibrillization of α-syn.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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In vitro fibrillization assays were performed on these five dopamine analogs.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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The in silico/in vitro approach presented here emerges as a possible strategy for identifying ligands interfering with such a complex process as the fibrillization of an unstructured protein.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Based on these results, we propose that: (i) the DOP mimics may interfere with the fibrillization of α-syn, although to a lesser extent than DOP and (ii) the ligands, that show the strongest binding to α-syn, i. e 6-aminoindole, and 5-hydroxyindole, and
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Human α-syn was then used in the amyloid fibrillization experiments in the presence and absence of the test ligands.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Exploiting this fact, we applied an integrated computational and experimental approach to find alternative ligands that might modulate the fibrillization of α-syn.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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Thus, we predicted that these ligands might have a weaker inhibitory effect on fibrillization than DOP. in vitro fibrillization assay.
PLoS ONE Alerts: New Articles Diane Latawiec et al. 2010
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