fibrillization love

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. The formation of fibrils

Etymologies

Sorry, no etymologies found.

Examples

  • Human α-syn was then used in the amyloid fibrillization experiments in the presence and absence of the test ligands.

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  • Based on these results, we propose that: (i) the DOP mimics may interfere with the fibrillization of α-syn, although to a lesser extent than DOP and (ii) the ligands, that show the strongest binding to α-syn, i. e 6-aminoindole, and 5-hydroxyindole, and

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  • Exploiting this fact, we applied an integrated computational and experimental approach to find alternative ligands that might modulate the fibrillization of α-syn.

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  • The in silico/in vitro approach presented here emerges as a possible strategy for identifying ligands interfering with such a complex process as the fibrillization of an unstructured protein.

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  • We observed the kinetics of the fibrillization process and analyzed the reaction end products by AFM to obtain spatially resolved information of their morphology.

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  • Thus, we predicted that these ligands might have a weaker inhibitory effect on fibrillization than DOP. in vitro fibrillization assay.

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  • In vitro fibrillization assays were performed on these five dopamine analogs.

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  • Moreover, the presence (B, C) or absence (E, F) of ThT did not show any effect upon the inhibitory action of DOP on α-syn fibrillization. doi: 10.1371/journal. pone.0009234.g004

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  • The inhibitory effect of DOP on the α syn fibrillization was clearly observed when the assay was run in the presence of DOP.

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  • Herrera FE, Chesi A, Paleologou KE, Schmid A, Munoz A, et al. (2008) Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region.

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