Definitions

from The American Heritage® Dictionary of the English Language, 5th Edition.

  • adjective Relating to or being the initial stage of something:
  • adjective Being a drug or therapy that is the standard or initial treatment for a disease or condition.
  • adjective Performing the most basic tasks or interacting directly with customers, patients, or clients; frontline.

Etymologies

Sorry, no etymologies found.

Examples

  • Over the next five to six years, these new clinical trials will evaluate treatment alternatives for diseases for which antibiotics are prescribed most often, including acute otitis media (middle ear infections), community-acquired pneumonia and diseases caused by Gram-negative bacteria, which frequently are resistant to first-line antibiotics.

    Antimicrobial Resistance: 8 Large NIH Trials Seek To Preserve The Usefulness Of Antibiotics

  • Over the next five to six years, these new clinical trials will evaluate treatment alternatives for diseases for which antibiotics are prescribed most often, including acute otitis media (middle ear infections), community-acquired pneumonia and diseases caused by Gram-negative bacteria, which frequently are resistant to first-line antibiotics.

    Antimicrobial Resistance: 8 Large NIH Trials Seek To Preserve The Usefulness Of Antibiotics

  • The company said it continues to expect a decision from European regulators in the first half of this year on using Revlimid as a first-line treatment for the blood cancer multiple myeloma.

    Celgene to Acquire Biotech Firm Avila

  • Regulators have become wary of PFS, especially for first-line treatments.

    Roche to File Cancer Drug

  • The EMA panel, whose opinions are usually followed by the European Commission, said it is recommending that Avastin in combination with chemotherapy Xeloda should be extended to include first-line treatment of patients with metastatic-breast cancer in whom treatment with other chemotherapy options isn't considered appropriate.

    Roche's Avastin Drug Gets Boost in Europe

  • "We have not yet reflected the use of the drug in liver, gastric and first-line breast cancer, with results expected during 2012 to 2104, which, if positive, could double our current forecast," he said.

    Novartis Tumor Pill Wins European Approval

  • The Drugs for Neglected Diseases Initiative says the goal is to develop a first-line therapy for children that is effective, available and affordable.

    New Initiative Provides Better Treatment for Pediatric AIDS

  • However, WestLB analyst Norbert Barth believes Bristol-Myer Squibb's Co. and Pfizer Inc.'s Eliquis has the potential to become the first-line treatment option for the atrial fibrillation indication, whereas Xarelto might be used in more advanced stages, limiting the product's overall peak sales potential.

    Bayer Rises on U.S. Approval for Blood Thinner

  • Bristol said a separate study is testing brivanib as a potential first-line treatment in newly diagnosed liver-cancer patients.

    Bristol-Myers Drug Misses Survival Goal in Liver-Cancer Trial

  • GM Brian Burke said April 28 that there were "no developments" with restricted free agent RW Nikolai Kulemin, who saw some first-line duty in 2009-10. —

    Toronto Maple Leafs Team Report

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