Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A benzodiazepine antagonist used to counter drowsiness caused by benzodiazepines.

Etymologies

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Examples

  • Isolated in 1981, flumazenil is an imidazobenzodiazepine capable of blocking the centrally mediated effects of benzodiazepines at the receptor level. 4 Its utility may parallel that of naloxone in opiate toxicity; however, controversy over its use in the emergency department persists. 5

    Flumanazil

  • The pharmacologic profile of flumazenil is unaltered in the presence of benzodiazepine agonists and the kinetics profiles of those benzodiazepines are unaltered by flumazenil. 7,10

    Flumanazil

  • After IV administration, flumazenil plasma concentrations follow a two compartment model with an initial distribution half-life ofseven to 15 minutes and a terminal half-life of 41 to 79 minutes.

    Flumanazil

  • Klotz U, Kanto J. Pharmacokinetics and clinical use of flumazenil (Ro 15-1788).

    Flumanazil

  • The duration and degree of reversal are related to the plasma concentration of the benzodiazepine as well as the dose of flumazenil. 7,10

    Flumanazil

  • Adverse effects most frequently associated with flumazenil alone were limited to dizziness, injection site pain, increased sweating, headache and abnormal or blurred vision.

    Flumanazil

  • Moreover in polydrug ingestions unresponsive to flumazenil no seizure activity or arrhythmias occurred.

    Flumanazil

  • Hojer J, Baehrendtz S, Matell G, Gustaffson L. Diagnostic utility of flumazenil in coma with suspected poisoning: a double blind, randomized controlled study.

    Flumanazil

  • An imidazobenzodiazepine derivative, flumazenil antagonizes the actions of benzodiazepines on the CNS.

    Flumanazil

  • O'Sullivan reported a significant increase in the GCS scores (in relation to their baseline) for the subgroups receiving flumazenil with confirmed benzodiazepine overdoses and mixed overdoses with benzodiazepines.

    Flumanazil

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