fluoropyrimidine love

fluoropyrimidine

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License.

  • noun Any of many fluorine substitution products of pyrimidine or its derivatives; especially such antimetabolites used to treat cancer

Etymologies

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Examples

  • * A fluoropyrimidine (Xeloda or intravenous 5-FU) and cisplatin every 3 weeks for 6 cycles.

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  • * A fluoropyrimidine (Xeloda or intravenous 5-FU) and cisplatin every 3 weeks for 6 cycles.

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  • As defined, the 1st-line regimen must comprise a platinum-containing compound (cisplatin, carboplatin, or oxaliplatin) and a fluoropyrimidine

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  • This phase II multicentre study was designed to evaluate the efficacy and safety of mapatumumab in patients with colorectal cancer (CRC) who had failed to respond to, were intolerant to, or not candidates for fluoropyrimidine, oxaliplatin, and irinotecan-based regimens.

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  • An Article published Online First by The Lancet says that for patients with HER2-positive advanced gastric cancer, addition of tastuzumab to standard cisplatinum/fluoropyrimidine chemotherapy results in a median survival of 13.8 months, compared with 11.1 months with chemotherapy alone.

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  • Vectibix was approved in the United States in September 2006 as a monotherapy for the treatment of patients with EGFR expressing mCRC after disease progression on or following fluoropyrimidine -, oxaliplatin -, and irinotecan-containing chemotherapy regimens.

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  • KRAS after failure of fluoropyrimidine -, oxaliplatin -, and irinotecan-containing chemotherapy regimens.

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  • HER2-positive advanced gastric cancer, found that the addition of trastuzumab to standard cisplatin/fluoropyrimidine chemotherapy resulted in a median survival of 13.8 months, compared with 11.1 months for patients who received chemotherapy alone -- a 26 percent difference.

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  • KRAS after failure of fluoropyrimidine -, oxaliplatin -, and irinotecan-containing chemotherapy regimens.

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  • Vectibix has been approved for the treatment of EGFR-expressing, metastatic colorectal cancer that has progressed on or following fluoropyrimidine -, oxaliplatin -, and irinotecan-containing chemotherapy regimens.

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