from Wiktionary, Creative Commons Attribution/Share-Alike License
- n. Plural form of frameshift.
Sorry, no etymologies found.
I assume that when we say mutation, the consensus definition is not simply single nucleotide alterations or frameshifts.
Once the researchers suspected the MLL2 gene, follow-up sequencing using the traditional and highly accurate Sanger DNA sequencing method, more capable of reliably detecting frameshifts, was used to identify additional MLL2 loss-of-function gene variants, which lead to a loss of function in two of the three remaining cases.
This results in translational frameshifts that access alternative open reading frames downstream, generating the V and W/I proteins.
Most of these mutations were expressed as frameshifts or splicing errors and resulted in no or very little IL2RG mRNA being expressed as shown in Injection of Il2rg ZFN-encoding mRNA into rat embryos induced targeted loss-of-function mutations.
They may be used to produce frameshifts or small in-frame deletions such as the 3-bp deletion that we observed.
A variety of pseudogene annotations from multiple sources were pooled and filtered to obtain a subset of sequences that have significant mid-sequence disablements (frameshifts and premature stop codons), and that have clear evidence of full-length mRNA transcription.
We’re aware of no mechanism that could be targeting these frameshifts in any way.