Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun biochemistry
glycosylation usingfucose moieties
Etymologies
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Examples
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Previous studies of ileal mucus in CF neonates with MI have demonstrated increased fucosylation.
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Thomsson KA, Hinojosa-Kurtzberg M, Axelsson KA, Domino SE, Lowe JB, et al. (2002) Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase.
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[42], [43] CF gene knockout mice, whose main pathology is intestinal mucous obstruction, have increased fucosylation and increased FUT2 expression.
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Devereux G, King A (1990) Abnormal fucosylation of ileal mucus in cystic fibrosis: I.
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Reduced POFUT1 levels might affect Notch trafficking or overall O-fucosylation.
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Whether the context-dependent effects of Notch receptor glycosylation by FNG reflect different requirements of distinct developmental processes for O-fucosylation by POFUT1 is unclear.
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Alternatively, reduced O-fucosylation might preferentially affect sites that are substrates for LFNG and thus important for somite formation and patterning.
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