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- n. glycosylation using fucose moieties
Sorry, no etymologies found.
Previous studies of ileal mucus in CF neonates with MI have demonstrated increased fucosylation.
Thomsson KA, Hinojosa-Kurtzberg M, Axelsson KA, Domino SE, Lowe JB, et al. (2002) Intestinal mucins from cystic fibrosis mice show increased fucosylation due to an induced Fucalpha1-2 glycosyltransferase.
,  CF gene knockout mice, whose main pathology is intestinal mucous obstruction, have increased fucosylation and increased FUT2 expression.
Devereux G, King A (1990) Abnormal fucosylation of ileal mucus in cystic fibrosis: I.
Reduced POFUT1 levels might affect Notch trafficking or overall O-fucosylation.
Whether the context-dependent effects of Notch receptor glycosylation by FNG reflect different requirements of distinct developmental processes for O-fucosylation by POFUT1 is unclear.
Alternatively, reduced O-fucosylation might preferentially affect sites that are substrates for LFNG and thus important for somite formation and patterning.