from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. Any disease or malfunction that affects the production of gamma globulin and related immunoglobulins

from WordNet 3.0 Copyright 2006 by Princeton University. All rights reserved.

  • n. a disturbance in the synthesis of immunoglobulins; proteins having antibody activity increase greatly in the blood


Sorry, no etymologies found.


  • Michael Emery, a 68-year-old retired engineer in Bonita Springs, Fla., says his doctor gave him a free one-month subscription to help him learn more about his rare condition called monoclonal gammopathy of undetermined significance, or MGUS.

    Online Records Get Patients Involved in Care

  • Do patients fare better when they're told they suffer from POEMS, or the Crow-Fukase syndrome of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes?

    Operation SMARM

  • Waldenstrom's Macroglobulinemia is a distinct lymphoproliferative disorder characterized by bone marrow infiltration with lymphoplasmacytic cells, along with an IgM monoclonal gammopathy.

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  • As karyotyping and single nucleotide polymorphism-based mapping analysis identify a minimal common deletion region involving the 1p21 locus, we investigated the prevalence and prognostic significance of del (1p21) in 203 MM patients undergoing high-dose therapy and autologous SCT. 1p21 status was also evaluated in 16 patients with monoclonal gammopathy of undetermined significance (MGUS) and 41 patients with plasma cell leukemia (PCL).

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  • Lemon was in Memorial Hermann Southwest Hospital for nine days before a doctor concluded he had POEMS Syndrome, an acronym for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome.

    The Facts: News

  • Offord JR, Larson DR et al. Long-term follow-up of IgM monoclonal gammopathy of undetermined significance.

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  • Comelli M, Morel P et al. Prognostic validation of the international classification of immunoglobulin M gammopathies: a survival advantage for patients with immunoglobulin M monoclonal gammopathy of undetermined significance?

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  • Larson DR, Plevak MF et al. Long-term follow-up of IgM monoclonal gammopathy of undetermined significance.

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  • Bradwell AR, Clark RJ et al. Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance (MGUS).

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  • Monoclonal gammopathy of undetermined significance, Waldenstrom macroglobulinemia, AL amyloidosis, and related plasma cell disorders: diagnosis and treatment.

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