from The American Heritage® Dictionary of the English Language, 4th Edition

  • n. A calcium-dependent actin-binding protein that modulates actin filament length and gelation and thus influences the structure of the cytoskeleton and plays a key role in cellular motility and differentiation.

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. An actin-binding protein that is a key regulator of actin filament assembly and disassembly.


gel(ation) + sol- (as in dissolve, from its turning actin from a semi-solid into a fluid) + -in.
(American Heritage® Dictionary of the English Language, Fourth Edition)


  • Arai M, Bandura JL, Kwiatkowski DJ (1998) Advillin (p92): a new member of the gelsolin/villin family of actin regulatory proteins.

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  • The mechanism of BCL2 regulation of cell adhesion and motility may involve formation of a complex containing BCL2, actin, and gelsolin, which appears to functionally decrease the severing activity of gelsolin.

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  • Thus, the formation of BCL2 and gelsolin complexes (which possibly contain other proteins) appears to play a critical role in the regulation of cell adhesion and migration.

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  • Then there’s gelsolin, glyceraldye 3 phosphate dehydrogenase, alpha enolase, argininosuccinate lyase, NADPH dependent reductase.

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