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Pfizer Inc voluntarily halted U.S. sales of Mylotarg, also known as gemtuzumab, after a study showed that adding it to chemotherapy did not extend survival for patients with previously untreated acute myeloid leukemia AML, an aggressive bone marrow cancer.
A second relapse of leukemia 332 days after transplantation led to reinduction therapy with cytarabine and gemtuzumab, and on day 391, he received a second stem-cell transplant from the same donor after a single dose of whole-body irradiation.
In the study, MRD measures were also used to determine which patients received the drug gemtuzumab ozogamicin.
Mylotarg (gemtuzumab ozogamicin) was given the green light in May 2000 under the US Food and
Instead of having a patient's eyes glaze over while they described a new "gemtuzumab ozogamicin" and how it might affect "basal metabolic organ functions," the oncologists and hematologists found Doug to be a fascinated patient who held as much hope and confidence in the science as they did, often following up by reading the latest research on his laptop from the hospital bed during treatment.