Definitions
from Wiktionary, Creative Commons Attribution/Share-Alike License.
- noun Plural form of
globin .
Etymologies
Sorry, no etymologies found.
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Examples
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It is worth mentioning that Thalassemia is the result of a genetic defect leading to severe shortages in the production of particular proteins in the blood 'globins' ', which is the main component of the haemoglobin found in red blood cell.
AME Info Latest News 2009
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Why is it that all vertebrates seem to have related genes for globins?
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We know that we all (as in all life) have structurally similar ribosomal RNA, F1/F0 ATPases and globins, derived at one point from common ancestor genes as they have sequence similarities that can connect any life form to any other (through intermediaries).
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The elucidation of this structure and its resemblance to the mammalian globins as determined by Perutz and Kendrew in their classical studies suggested for the first time a universal globin fold.
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GLB-1* displays the classical three-over-three alfa helical sandwich of vertebrate globins, assembled in a homodimer associated through facing E - and F-helices.
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[2] The causal mutations are those within genes responsible for beta globins (blood proteins).
CreationWiki - Recent changes [en] Ashcraft 2010
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GLB-1 exhibits high ligand affinity, which is, however, lower than in other globins with the same distal TyrB10-GlnE7 amino-acid pair.
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[2] The causal mutations are those within genes responsible for beta globins (blood proteins).
CreationWiki - Recent changes [en] Ashcraft 2010
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We expressed the globins in a bacterial system, characterized the purified proteins by optical and resonance Raman spectroscopy, measured the kinetics and equilibria of O2 binding and determined the crystal structure of GLB-1* (CysGH2Ser mutant).
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Although their translated amino acid sequences fit the globin fold, a variety of amino-acid substitutions and extentions generate a wide structural diversity among the putative globins.
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