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Examples
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How does mTORC1 regulate the glucolipotoxic ER stress in β-cells?
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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We then studied whether translational inhibition of IRE1α by cycloheximide may alleviate the ER stress response in β-cells exposed to glucolipotoxic conditions.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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To further study the effects of translation inhibition on IRE1α synthesis in stressed β-cells, INS-1E β-cells were incubated under glucolipotoxic conditions with and without a low concentration (0.2 mmol / l) of the translational inhibitor cycloheximide.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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In summary, mTORC1 probably leads to both insulin resistance and β-cell apoptosis under glucolipotoxic conditions by promoting ER stress.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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However, the overall induction of ER stress by glucose is lower compared to that induced by palmitate, mainly under glucolipotoxic conditions.
PLoS ONE Alerts: New Articles Etti Bachar et al. 2009
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