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- noun Plural form of
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"For many years it has been known that proteins called glycophorins are used by the parasite to gain entry into the red cell."
For many years it has been known that proteins called glycophorins are used by the parasite to gain entry into the red cell, "said Jose A. Stoute, senior investigator and team leader, Department of
According to the researchers, the reasons malaria may use the CR1 protein instead of glycophorins are if the parasite encounters a variant that lacks the glycophorin receptor; if the immune system mounts a response against parasite proteins involved in the dominant pathway due to a previous infection; or if the host were to be vaccinated with a vaccine that blocks the glycophorin pathway.
"Our findings suggest that for many malaria strains, CR1 is an alternative receptor to glycophorins on intact red cells," Stoute said.
Because infection can take place without glycophorins, researchers suspected that another protein is also involved.