glycosylphosphatidylinositol love

glycosylphosphatidylinositol

Definitions

from Wiktionary, Creative Commons Attribution/Share-Alike License

  • n. A glycolipid, containing inositol as the sugar entity, that is involved in the posttranslational modification of protein

Etymologies

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Examples

  • GPC3 is a member of the glypican family of glycosylphosphatidylinositol-anchored cell-surface heparan sulfate proteoglycans.

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  • Malengo G, Andolfo A, Sidenius N, Gratton E, Zamai M, et al. (2008) Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: functional dynamics of the glycosylphosphatidylinositol-anchored urokinase plasminogen activator receptor.

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  • Bruneau JM, Magnin T, Tagat E, Legrand R, Bernard M, et al. (2001) Proteome analysis of Aspergillus fumigatus identifies glycosylphosphatidylinositol-anchored proteins associated to the cell wall biosynthesis.

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  • Their proposed tranlation products have a glycosylphosphatidylinositol (GPI) anchor and are located in the cell wall of growing hyphae

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  • Smith TK (2006) The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol.

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  • The effect of LPS on myeloid cells is mediated by a multicomplex receptor system in which CD14, a glycosylphosphatidylinositol-anchored glycoprotein, and Toll-like receptor 4 are the major players.

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  • This technique relies on the previously reported "tethered-toxin" technology for cell-autonomous modulation of ionic conductances via heterologous expression of subtype-specific peptide ion channel toxins as chimeric fusion proteins tethered to the plasma membrane with a glycosylphosphatidylinositol

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  • Ephrin-A5 is a glycosylphosphatidylinositol-anchored protein expressed in muscles and is a ligand for a group of membrane-bound receptor tyrosine kinases, the Ephs. Motor neurons express EphA4 receptors

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  • Sunyach C, Jen A, Deng J, Fitzgerald KT, Frobert Y, et al. (2003) The mechanism of internalization of glycosylphosphatidylinositol-anchored prion protein.

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  • This protein attaches to cell membranes by way of an anchor made of sugar and lipid components (a glycosylphosphatidylinositol, GPI) anchor.

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